Clinical evidence

The history of EBAMed

The milestones we have achieved, what we have built and published, and our next objectives.

01 / Milestones

From a thesis in Geneva to dual-gated beam delivery

  1. Founded in Geneva

    Adriano Garonna, technical director of the TERA Foundation from 2016 to 2018, co-founds EBAMed, External Beam Ablation, with Ugo Amaldi (CERN, founder of TERA and CNAO), Giovanni Leo and Douglas Packer (Mayo Clinic). The thesis: image the heart itself, in real time, and let the beam wait for it. A CHF 1.2 M seed round follows in 2019, then the Mayo Clinic Business Accelerator and a €2.4 M EIC Accelerator grant in 2020.

    CERN Courier ↗ · EBAMed news ↗

  2. First patient enrolled

    Prospective imaging study opens at Policlinico San Matteo, Pavia. Can transthoracic ultrasound see the beating heart well enough, in real VT patients, to steer a proton beam?

  3. First page of Casula et al., Feasibility of an automatic ultrasonographic image acquisition system associated with an artificial intelligence algorithm for real-time monitoring of cardiac motion during cardiac radio-ablation, Frontiers in Cardiovascular Medicine, 2022. First page of Perrin et al., Case report: treatment planning study to demonstrate feasibility of transthoracic ultrasound guidance to facilitate ventricular tachycardia ablation with protons, Frontiers in Cardiovascular Medicine, 2022.

    Automatic acquisition and tracking

    Front Cardiovasc Med: an automatic ultrasound acquisition system with an AI algorithm, monitoring cardiac motion in real time during radioablation. Paired with a treatment-planning case report showing transthoracic ultrasound guiding proton VT ablation.

    Front Cardiovasc Med ↗ · planning case report ↗

  4. Demonstrator in the clinic

    Prospective cardiac ultrasound imaging study with the demonstrator system (NCT05850741). The tracking hardware and algorithm, on patients, in the room.

    NCT05850741 ↗

  5. First page of Cengel et al., Cardiorespiratory-gated cardiac proton radiotherapy using a novel ultrasound guidance system, Clinical and Translational Radiation Oncology, 2024.

    Cardiorespiratory-gated proton delivery

    Clin Transl Radiat Oncol: cardiac proton radiotherapy gated on both breathing and heartbeat, using the ultrasound guidance system. The gate opens where diastole meets end-expiration.

    Clin Transl Radiat Oncol ↗

  6. First page of Rossi et al., Integration of ultrasound-guided motion management into proton therapy treatment plans for ventricular tachycardia non-invasive radio ablation, Journal of Applied Clinical Medical Physics, 2025.

    Into the treatment plan

    J Appl Clin Med Phys: ultrasound-guided motion management integrated into proton treatment plans for VT radioablation. The gate stops being an add-on and becomes part of the dose calculation. Large-animal gated proton ablation under CardioKit guidance, with Mayo Clinic, runs in parallel.

    J Appl Clin Med Phys ↗ · large-animal study ↗

  7. Ahead

    First-in-human

    First-in-human trials at clinical partner centers, funded by the 2023 Series A. The full chain, ultrasound tracking, dual gate and proton beam, on patients.

02 / The full record

A detailed timeline of clinical evidence

PDF · 18 pages · 560 KB

Extended clinical evidence

The catheter era, proof in animals, photons and particles in patients, motion management. From the first accidental catheter ablation in 1979 to gated proton delivery, with references to publications.

Download the PDF

Prefer it in the browser? The same record is on the full record page.